Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling

Table 3 Estimates from linear mixed-effect models predicting pulmonary arterial impedance and total and oscillatory hydraulic power

	Z_c [dyn × sec × cm⁻⁵]	Z₀ [dyn × sec × cm⁻⁵]	W_T [mW]	W_Osc [mW]
Intercept	132.8 [96.7 to 169.0]	267.7 [132.7 to 402.7]	1608.7 [1440.1 to 1777.3]	386.7 [320.4 to 453.0]
HPV	15.0 [− 34.1 to 64.1]	609.7 [460.8 to 758.5]^‡	888.2 [763.6 to 1012.8]^‡	273.4 [225.8 to 321.0]^‡
PE	40.6 [− 8.2 to 89.4]	251.1 [103.2 to 399.1]^‡	386.9 [263.1 to 510.7]^‡	81.9 [34.6 to 129.2]^‡
Q_ECMO	13.4 [1.7 to 25.1]*	123.6 [88.1 to 159.1]^‡	− 299.5 [− 329.2 to − 269.8]^‡	− 71.8 [− 83.1 to − 60.4]^‡
Q_ECMO × HPV	− 7.1 [− 25.3 to 11.1]	− 27.2 [− 82.4 to 28.0]	− 123.7 [− 169.9 to − 77.4]^‡	− 40.0 [− 57.7 to − 22.4]^‡
Q_ECMO × PE	9.1 [− 8.9 to 27.2]	0.7 [− 54.1 to 55.5]	− 80.8 [− 126.7 to − 35.0]^‡	− 16.5 [− 34.0 to 1.1]
Adjusted r²	0.10	0.38	0.73	0.62

Estimates from regression are shown with 95% CI. The intercept is the estimated value at 0 L/min Q_ECMO for baseline condition. HPV and PE estimates the change if the respective condition is present. Q_ECMO estimates the change per change of 1 L/min. Q_ECMO × HPV and Q_ECMO × PE estimates the additional change per change of 1 L/min of Q_ECMO during the respective condition. Q_ECMO: ECMO blood flow [L/min]. HPV: hypoxic pulmonary vasoconstriction. PE: pulmonary embolism. Z_c: characteristic pulmonary vascular impedance averaged over frequencies 2–15 Hz. Z₀: input resistance (impedance at 0 Hz). W_T: total hydraulic power. W_Osc: oscillatory hydraulic power. mW: milliwatt. *p < 0.05. ^‡p < 0.001

ISSN: 2052-0492