Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling

Table 4 Estimates from linear mixed-effect models predicting ventriculo-arterial coupling and ejection fraction

	VA coupling_insp	VA coupling_Exp	EF_Insp	EF_Exp
Intercept	1.4 [1.2 to 1.6]	2.1 [1.8 to 2.3]	59.4 [55.5 to 63.3]	66.0 [63.0 to 69.1]
HPV	0.2 [0.0 to 0.4]^†	− 0.1 [− 0.3 to 0.1]	2.0 [− 1.1 to 5.1]	− 1.3 [− 3.4 to 0.8]
PE	0.0 [− 0.1 to 0.2]	− 0.2 [− 0.4 to 0.0]	− 0.3 [− 3.4 to 2.8]	− 3.7 [− 5.8 to − 1.6]^‡
Q_ECMO	− 0.1 [− 0.2 to − 0.1]^‡	0.0 [− 0.0 to 0.1]	− 4.2 [− 4.9 to − 3.4]^‡	0.0 [− 0.5 to 0.5]
Q_ECMO × HPV	0.1 [0.0 to 0.1]^†	− 0.0 [− 0.1 to 0.1]	2.7 [1.6 to 3.9]^‡	− 0.1 [− 0.9 to 0.6]
Q_ECMO × PE	− 0.0 [− 0.1 to 0.0]	0.0 [− 0.0 to 0.1]	− 1.2 [− 2.4 to − 0.1]*	0.8 [0.0 to 1.5]*
Adjusted r²	0.49	0.45	0.54	0.44

Estimates from regression are shown with 95% CI. The intercept is the estimated value at 0 L/min Q_ECMO for baseline condition. HPV and PE estimates the change if the respective condition is present. Q_ECMO estimates the change per change of 1 L/min. Q_ECMO × HPV and Q_ECMO × PE estimates the additional change per change of 1 L/min of Q_ECMO during the respective condition. Q_ECMO: ECMO blood flow [L/min]. HPV: hypoxic pulmonary vasoconstriction. PE: pulmonary embolism. *p < 0.05. ^†p < 0.01. ^‡p < 0.001

ISSN: 2052-0492