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Table 1 Baseline characteristics in the two cohorts

From: Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation

Variable

Derivation

Validation

Non-survivor n = 252 (%)

Survivor n = 1240 (%)

P value

Non-survivor n = 83 (%)

Survivor n = 345 (%)

P value

Sex

  

0.0049

  

0.9815

 Female

83 (32.9)

528 (42.6)

 

35 (42.2)

145 (42.0)

 

 Male

169 (67.1)

712 (57.4)

 

48 (57.8)

200 (58.0)

 

Age

73.4 (13.2)

69.8 (15.4)

< 0.0001

71.6 (14.2)

67.9 (14.1)

0.0331

Body weight

56.3 (15.1)

55.6 (13.2)

0.5587

55.6 (12.3)

57.2 (14.1)

0.3555

Antithrombin activity (%)

43.5 (12.9)

48.4 (12.2)

< 0.0001

46.0 (13.7)

47.3 (13.2)

0.4437

JAAM DIC score

5.6 (1.3)

5.6 (1.4)

0.7838

6.3 (1.4)

6.1 (1.4)

0.4895

 SIRS

0.7 (0.4)

0.8 (0.4)

0.2293

0.8 (0.4)

0.8 (0.4)

0.7256

 Platelet

2.1 (1.2)

2.0 (1.2)

0.0858

2.4 (1.0)

2.4 (1.0)

0.9432

 PT-INR

0.9 (0.3)

0.8 (0.4)

0.0044

0.9 (0.3)

0.9 (0.3)

0.9033

 FDP

1.8 (1.2)

2.0 (1.2)

0.0820

2.2 (1.1)

2.1 (1.1)

0.3805

SOFA score

11.8 (3.9)

8.9 (3.7)

< 0.0001

12.6 (3.5)

11.3 (3.5)

0.0028

 Respiration

2.3 (1.2)

1.7 (1.2)

< 0.0001

2.3 (1.3)

2.1 (1.2)

0.1866

 Coagulation

2.1 (1.1)

1.8 (1.1)

0.0029

1.9 (1.3)

1.9 (1.2)

0.6331

 Liver

0.9 (1.1)

0.7 (0.9)

0.0018

0.8 (0.9)

0.9 (1.1)

0.2681

 Cardiovascular

2.7 (1.5)

2.1 (1.7)

< 0.0001

3.1 (1.3)

2.9 (1.4)

0.2443

 GCS

2.3 (1.5)

1.4 (1.4)

< 0.0001

2.1 (1.3)

1.4 (1.3)

< 0.0001

 Renal

1.6 (1.3)

1.2 (1.3)

0.0001

2.4 (1.3)

2.1 (1.3)

0.0155

Antithrombin concentrate

 Daily dose (IU)

1594.7 (434.5)

1576.0 (457.7)

0.5498

   

 Duration (day)

3.5 (1.8)

3.2 (1.9)

0.0157

   

Co-administration

 Heparin

45 (17.9)

188 (15.2)

0.2951

5 (6.0)

29 (8.4)

0.4713

 Protease inhibitor

51 (20.2)

254 (20.5)

1.0000

21 (25.3)

86 (24.9)

0.9437

 Thrombomodulin

154 (61.1)

711 (57.3)

0.2938

42 (50.6)

194 (56.2)

0.3545

 Renal replacement therapy

122 (48.4)

332 (26.8)

< 0.0001

44 (53.0)

151 (43.8)

0.1290

 PMX-DHP

35 (13.9)

191 (15.4)

0.6298

35 (42.2)

145 (42.0)

0.9815

 Mechanical ventilation

185 (73.4)

623 (50.2)

< 0.0001

76 (91.6)

256 (74.2)

0.0011

  1. Continuous variables are presented as means with standard deviation (SD), and categorical variables are presented as numbers with percentages
  2. JAAM Japanese Association for Acute Medicine, DIC disseminated intravascular disease, SIRS systemic inflammatory response syndrome, PT-INR prothrombin time-international normalized ratio, FDP fibrin/fibrinogen degradation products, SOFA Sequential Organ Failure Assessment, GCS Glasgow Coma Scale, IU international unit, PMX-DHP direct hemoperfusion with Polymyxin B immobilized fiber
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Journal of Intensive Care

ISSN: 2052-0492