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Table 2 Univariate and multivariate Cox regression analysis in the derivation cohort

From: Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Male

1.46 (1.12, 1.90)

0.005

1.53 (1.15, 2.04)

0.004

Age

1.02 (1.01, 1.03)

0.001

1.02 (1.01, 1.03)

0.001

Antithrombin activity (Day3)

0.98 (0.98, 0.99)

< 0.0001

0.99 (0.99, 1.00)

0.020

Delta JAAM DIC score

0.74 (0.70, 0.79)

< 0.0001

0.83 (0.77, 0.89)

< 0.0001

 Delta SIRS

0.52 (0.42, 0.63)

< 0.0001

  

 Delta PT-INR

0.45 (0.35, 0.57)

< 0.0001

  

 Delta FDP

0.89 (0.81, 0.98)

0.975

  

Delta SOFA score

0.39 (0.33, 0.46)

< 0.0001

0.45 (0.38, 0.55)

< 0.0001

 Delta respiration

0.75 (0.66, 0.84)

< 0.0001

  

 Delta coagulation

0.72 (0.64, 0.80)

< 0.0001

  

 Delta liver

0.61 (0.53, 0.70)

< 0.0001

  

 Delta cardiovascular

0.73 (0.67, 0.79)

< 0.0001

  

 Delta GCS

0.70 (0.63, 0.78)

< 0.0001

  

 Delta renal

0.75 (0.66, 0.86)

< 0.0001

  
  1. Delta = Day0–Day3
  2. JAAM Japanese Association for Acute Medicine, DIC disseminated intravascular disease, SIRS systematic inflammatory response syndrome, PT-INR prothrombin time-international normalized ratio, FDP fibrin/fibrinogen degradation products, SOFA Sequential Organ Failure Assessment, GCS Glasgow Coma Scale, HR hazard ratio, CI confidence interval
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Journal of Intensive Care

ISSN: 2052-0492