Fig. 2

Trajectories of A: mental health and cognition and B: physical function in ICU- and non-ICU-treated patients for COVID-19 up to 2 years after hospital discharge. Data are presented as estimated proportions or estimated means with standard errors obtained from Generalized Estimating Equations analysis. A Estimated proportions (patients with HADS-A ≥ 11 and HADS-D ≥ 11) and estimated means (total IES-R score and total CFQ score) are adjusted for age and sex, the fixed value for age was 60 years. B Data are presented as the percentage of normative values reached in 6MWT, 1MSTST, and HGS. Normative values in 6MWT are calculated using sex-, age-, height-, and weight-stratified equations described by Enright and Sherill [44], in 1MSTST using sex- and age-stratified reference values described by Strassman and colleagues [45], and in HGS using sex- and age-stratified reference values described by Dodds and colleagues [46]. We compared the 2-year trajectories between the ICU and non-ICU groups and the p value is presented above the horizontal brackets in each panel. A significant group difference at each time point is indicated by * < 0.05, ** < 0.01, and *** < 0.001. Within group trajectories are further presented in Supplementary Table S4. ICU Intensive Care Unit, HADS-A Hospital Anxiety and Depression Scale-subscale Anxiety, HADS-D Hospital Anxiety and Depression Scale-subscale Depression, IES-R Impact of Event Scale-Revised, CFQ Cognitive Failures Questionnaire, 6MWT 6 Min Walk Test, 6MWD 6 Min Walk Distance, 1MSTST 1 Min Sit-To-Stand Test, STS Sit-To-Stand, HGS Handgrip Strength