Fig. 1

Schematic of CKRT model. CVVH, continuous veno-venous hemofiltration. CVVHD, continuous veno-venous hemodialysis. Mass transfer within this CKRT model includes PK rate constants representing transfer from the central compartment to the filter (k₁₃), the filter to the central compartment (k₃₁), the filter to the cartridge, or non-blood fluid space within the filter (k₃₄), and then from the cartridge into the effluent (k₄₀); see Table S1 for details. The purple shaded area represents the CKRT module connected to the central compartment. Created with BioRender.com