Fig. 2

Comparison of model-informed precision dosing software-generated concentration–time profiles using observed cefepime plasma concentrations without (left panel) and with (right panel) inclusion of CKRT module for Patient 2. The closed circles are observed concentrations, the red solid line is the estimated concentration vs. time profile fitted to the observations and the red shaded area around the concentration–time profile is the 95th% percentile confidence interval. The blood flow rate was decreased from 200 mL/min to 100 mL/min at hour 12 of treatment, hence the inflection point in the predicted concentration–time profile at that point. Created with BioRender.com