Fig. 3
MCS from artificial patients with negligible residual kidney function (eGFR 5 mL/min/1.73 m2). CI, continuous infusion. q12 4 h, every 12 h as a 4-h infusion (EI, extended infusion). q12 30 m, every 8 h as a 30-min infusion (SI, standard infusion). q8 4 h, every 8 h as a 4-h infusion (EI). q8 30 m, every 8 h as a 30-min infusion (SI). Individual points represent the percentage of the 1000-fold simulated patients who achieved 100% fT > MIC, where 8 mg/L is 1xMIC and 32 mg/L is equivalent to 4xMIC. Black bars represent the PD target of 90% of population achieving 100% fT > MIC. Figure created with RStudio for Mac and BioRender