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Table 2 Initial presentation and laboratory data at diagnosis

From: Clinical characteristics and short-term outcomes of patients with critical acute pulmonary embolism requiring extracorporeal membrane oxygenation: from the COMMAND VTE Registry-2

 

Overall

Surgical intervention

Catheter intervention

Thrombolytic therapy

Anticoagulation only

Number

76

16

16

16

28

Initial presentation

     

 Out-of-hospital onset

60 (79.0%)

11 (68.8%)

12 (75.0%)

15 (93.8%)

22 (78.6%)

 Arrest/collapse at diagnosis

67 (88.2%)

12 (75.0%)

13 (81.3%)

15 (93.8%)

27 (96.4%)

 Arrest at diagnosis

52 (68.4%)

10 (62.5%)

11 (68.8%)

7 (43.8%)

24 (85.7%)

 Collapse at diagnosis

15 (19.7%)

2 (12.5%)

2 (12.5%)

8 (50.0%)

3 (10.7%)

 Concomitant DVT

41 (54.0%)

12 (75.0%)

10 (62.5%)

9 (56.3%)

10 (35.7%)

 ECMO use at hospital arrival

61 (80.3%)

13 (81.3%)

12 (75.0%)

12 (75.0%)

24 (85.7%)

Laboratory data at diagnosis

     

 WBC (/μL)

11,250 [9425–15,000]

10,150 [8937–19,450]

12,050 [8550–15,750]

11,350 [9900–14,100]

11,250 [9425–15,067]

 Hemoglobin (g/dL)

12.0 [10.1–14.3]

11.0 [8.9–13.3]

13.3 [10.0–14.6]

14.2 [11.8–16.0]

11.6 [9.7–13.7]

 Platelet (109/μL)

16.7 [11.6–23.7]

17.0 [10.5–24.3]

19.2 [14.6–22.6]

16.1 [12.4–22.3]

15.8 [10.5–25.6]

 Total bilirubin (mg/dL)

0.6 [0.4–0.8]

0.8 [0.7–1.45]

0.6 [0.4–0.8]

0.6 [0.5–0.8]

0.6 [0.3–0.8]

 AST (IU/L)

111 [43–230]

77 [41–144]

142 [35–252]

120 [29–222]

122 [59–274]

 ALT (IU/L)

80 [39–177]

47 [20–113]

85 [67–182]

54 [24–162]

114 [52–233]

 Serum creatinine (mg/dL)

1.03 [0.83–1.33]

0.94 [0.78–1.10]

0.96 [0.79–1.16]

1.13 [0.93–1.33]

1.09 [0.86–1.45]

 eGFR (mL/min/1.73m2)

49.9 [40.1–60.3]

50.1 [43.6–60.8]

51.0 [38.6–70.5]

52.9 [40.7–56.4]

43.5 [38.7–58.6]

 D-dimer (μg/mL)

28.1 [13–49]

33.2 [12.8–57.3]

26.3 [14.3–33.5]

21.5 [10.6–66.0]

34.5 [9.4–51.9]

 BNP (pg/mL)

225.6 [70.1–592.7]

605.2 [58.6–892.8]

330.1 [32.5–918.5]

307.7 [29.5–713.3]

183.9 [83.0–460.5]

  1. DVT deep vein thrombosis, ECMO extracorporeal membrane oxygenation, WBC white blood cell, AST aspartate aminotransferase, ALT alanine aminotransferase, eGFR estimated glomerular filtration rate, BNP brain natriuretic peptide. ECMO use at hospital arrival initiated immediately at diagnosis after hospital arrival. In the other group, ECMO was used as the condition worsened after starting initial treatment without ECMO