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Table 4 Clinical characteristics comparing the survivor and non-survivor at 30 days

From: Clinical characteristics and short-term outcomes of patients with critical acute pulmonary embolism requiring extracorporeal membrane oxygenation: from the COMMAND VTE Registry-2

 

Survivor

Non-survivor

Univariate odds ratio (95% CI)

Number

53

23

 

Baseline characteristics

   

 Gender, male

23 (43.4%)

11 (47.8%)

1.20 (0.44–3.19)

 Age (years)

59.3 ± 13.6

56.4 ± 16.0

0.99 (0.95–1.02)

 BMI (kg/m2)

24.0 ± 4.0

25.1 ± 5.5

1.06 (0.94–1.18)

 BMI ≥ 30 kg/m2

3 (5.7%)

4 (17.4%)

3.51 (0.72–17.16)

Comorbidity

   

 History of VTE

3 (5.7%)

1 (4.4%)

0.76 (0.07–7.69)

 History of PE

1 (1.9%)

1 (4.4%)

2.36 (0.14–39.51)

 History of DVT

3 (5.7%)

1 (4.4%)

0.76 (0.07–7.69)

 Chronic heart disease

5 (9.4%)

6 (26.1%)

3.39 (0.91–12.55)

 History of stroke

2 (3.8%)

0 (0%)

N/A

 COPD/asthma

1 (1.9%)

3 (13.0%)

7.8 (0.77–79.56)

 History of major bleeding

3 (5.7%)

2 (8.7%)

1.59 (0.25–10.20)

 Hypertension

23 (43.4%)

9 (39.1%)

0.84 (0.31–2.28)

 Diabetes

8 (15.1%)

3 (13.0%)

0.84 (0.20–3.52)

 Dyslipidemia

11 (20.8%)

2 (8.7%)

0.36 (0.07–1.79)

 Chronic kidney disease

9 (17.0%)

5 (21.7%)

1.36 (0.40–4.61)

 Dialysis

1 (1.9%)

0 (0%)

N/A

 Autoimmune disease

0 (0%)

2 (8.7%)

N/A

 Congenital coagulation defects

4 (7.6%)

3 (13.0%)

1.84 (0.38–8.96)

 Active cancer

3 (5.7%)

3 (13.0%)

2.50 (0.46–13.44)

Initial presentation

   

 Out-of-hospital onset

40 (75.5%)

20 (87.0%)

2.17 (0.55–8.49)

 Arrest/collapse at diagnosis

48 (90.6%)

19 (82.6%)

0.49 (0.12–2.04)

 Arrest at diagnosis

35 (66.0%)

17 (73.9%)

1.46 (0.49–4.34)

 Collapse at diagnosis

13 (24.5%)

2 (8.7%)

0.29 (0.06–1.42)

 ECMO use at hospital arrival

44 (83.0%)

17 (73.9%)

0.57 (0.18–1.88)

Laboratory data

   

 WBC (/μL)

13,200 [1000–15190]

10,800 [9125–14750]

1.00 (0.99–1.00)

 Hemoglobin (g/dL)

12 [9.7–14.3]

12.1 [10.9–14.6]

1.04 (0.88–1.23)

 Platelet (109/μL)

16.2 [12.6–24.4]

17.3 [9.3–20.4]

0.98 (0.93–1.04)

 Serum creatinine (mg/dL)

1.01 [0.81–1.19]

1.09 [0.92–1.38]

1.18 (0.70–1.98)

 eGFR (mL/min/1.73m2)

50.5 [40.8–60.7]

48.1 [36.3–56.6]

0.98 (0.95–1.01)

 Total bilirubin (mg/dL)

0.6 [0.4–0.9]

0.65 [0.4–0.8]

1.03 (0.69–1.54)

 D-dimer (μg/mL)

28.8 [12.5–53.9]

23.4 [12.8–36.8]

0.99 (0.98–1.01)

 BNP (pg/mL)

143.8 [36.5–4442.6]

800.1 [230.9–1365.1]

1.00 (1.00–1.01)

Treatment

   

 Surgical intervention

15 (28.3%)

1 (4.4%)

0.12 (0.01–0.93)

 Catheter intervention

10 (18.9%)

7 (30.4%)

1.88 (0.61–5.79)

 Thrombolytic therapy

13 (24.5%)

8 (34.8%)

1.64 (0.57–4.75)

 Anticoagulation only

17 (32.1%)

11 (47.8%)

1.94 (0.71–5.28)

  1. BMI body mass index, VTE venous thromboembolism, PE pulmonary embolism, DVT deep vein thrombosis, COPD chronic obstructive pulmonary disease, ECMO extracorporeal membrane oxygenation, WBC white blood cell, eGFR estimated glomerular filtration rate, BNP brain natriuretic peptide, N/A not applicable. The detailed definition of comorbidities is shown in supplementary appendix 2. The odds ratio indicates the risk of death based on the number of survivors