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Table 2 Interventions for patients with severe respiratory failure on mechanical ventilation

From: Impact of board-certified intensive care training facilities on choice of adjunctive therapies and prognosis of severe respiratory failure: a nationwide cohort study

 

Unmatched groups

Propensity score-matched groups

Certified (n = 30,588)

Non-certified (n = 36,317)

P value

Certified (n = 26,673)

Non-certified (n = 26,673)

P value

Sedative, n (%)

18,727 (61)

15,349 (42)

 < 0.001

15,743 (59)

12,633 (47)

 < 0.001

 Propofol

10,711 (35)

6436 (18)

 < 0.001

8831 (33)

5545 (21)

 < 0.001

 Dexmedetomidine

11,291 (37)

6842 (19)

 < 0.001

9479 (36)

5617 (21)

 < 0.001

 Midazolam

8143 (27)

7847 (22)

 < 0.001

6658 (25)

6516 (24)

0.150

Opioid, n (%)

15,863 (52)

7934 (22)

 < 0.001

13,189 (49)

6854 (26)

 < 0.001

 Fentanyl

15,400 (50)

7175 (20)

 < 0.001

12,750 (48)

6318 (24)

 < 0.001

 Morphine

632 (2.1)

817 (2.2)

0.10

578 (2.2)

584 (2.2)

0.86

Neuromuscular blockade, n (%)

3132 (10)

1182 (3.3)

 < 0.001

2546 (9.5)

1055 (4.0)

 < 0.001

 Rocuronium

2602 (8.5)

962 (2.6)

 < 0.001

2130 (8.0)

860 (3.2)

 < 0.001

 Vecuronium

578 (1.9)

225 (0.6)

 < 0.001

452 (1.7)

200 (0.7)

 < 0.001

Vasopressor, n (%)

12,471 (41)

10,731 (30)

 < 0.001

10,172 (38)

9370 (35)

 < 0.001

 Noradrenaline

10,734 (35)

6701 (19)

 < 0.001

8673 (33)

6063 (23)

 < 0.001

 Arginine vasopressin

2473 (8.1)

710 (2.0)

 < 0.001

1922 (7.2)

677 (2.5)

 < 0.001

 Dopamine

2751 (9.0)

5469 (15)

 < 0.001

2309 (8.7)

4623 (17)

 < 0.001

 Adrenaline

698 (2.3)

351 (1.0)

 < 0.001

550 (2.1)

312 (1.2)

 < 0.001

Inotropic agent, n (%)

2834 (9.3)

1795 (4.9)

 < 0.001

2380 (8.9)

1471 (5.5)

 < 0.001

 Dobutamine

2650 (8.7)

1729 (4.8)

 < 0.001

2232 (8.4)

1429 (5.4)

 < 0.001

 PDE inhibitor

313 (1.0)

118 (0.3)

 < 0.001

253 (0.9)

81 (0.3)

 < 0.001

Sivelestat, n (%)

1255 (4.1)

2548 (7.0)

 < 0.001

1096 (4.1)

2057 (7.7)

 < 0.001

 High-dose methylprednisolone, n (%)

4074 (13)

5415 (15)

 < 0.001

3587 (13)

4259 (16)

 < 0.001

 Low-dose methylprednisolone, n (%)

5359 (18)

6582 (18)

0.042

4756 (18)

4805 (18)

0.580

 Antibioticsa, n (%)

28,153 (92)

32,354 (89)

 < 0.001

24,414 (92)

24,079 (90)

 < 0.001

 Antifungal drugsb, n (%)

1373 (4.5)

1011 (2.8)

 < 0.001

1130 (4.2)

843 (3.2)

 < 0.001

 BAL during hospitalization, n (%)

726 (2.4)

484 (1.3)

 < 0.001

604 (2.3)

404 (1.5)

 < 0.001

 Early ENc, n (%)

8758 (29)

5092 (14)

 < 0.001

7396 (28)

4271 (16)

 < 0.001

 EN within 7 days, n (%)

16,361 (54)

10,178 (28)

 < 0.001

13,824 (52)

8518 (32)

 < 0.001

 PN within 7 days, n (%)

5226 (17)

6440 (18)

0.028

4374 (16)

5211 (20)

 < 0.001

 Early rehabilitationd, n (%)

10,289 (34)

10,860 (30)

 < 0.001

9021 (34)

7749 (29)

 < 0.001

 ECMO during hospitalization, n (%)

503 (1.6)

101 (0.3)

 < 0.001

369 (1.4)

96 (0.4)

 < 0.001

 RRT during hospitalization, n (%)

4563 (15)

2445 (6.7)

 < 0.001

3634 (14)

2144 (8.0)

 < 0.001

Tracheostomy, n (%)

7753 (25)

7445 (21)

 < 0.001

6700 (25)

5665 (21)

 < 0.001

 Timing of tracheostomy, day

11 (8.0–6)

14 (9.0–19)

 < 0.001

11 (8.0–16)

13 (9.0–19)

 < 0.001

Critical care units use, n (%)

22,627 (74)

10,881 (30)

 < 0.001

19,241 (72)

9157 (34)

 < 0.001

 Intensive care unit use

17,513 (57)

7826 (22)

 < 0.001

14,663 (55)

6580 (25)

 < 0.001

 High-care unit use

8844 (29)

3487 (9.6)

 < 0.001

7676 (29)

2954 (11)

 < 0.001

  1. Data are presented as n (%) or median (interquartile range)
  2. PDE phosphodiesterase, BAL bronchoalveolar lavage, EN enteral nutrition, PN parenteral nutrition, ECMO extracorporeal membrane oxygenation, RRT renal replacement therapy
  3. aPenicillins, cephalosporins, carbapenems, anti-methicillin-resistant Staphylococcus aureus drugs, quinolones, aminoglycosides, and others
  4. bMicafungin and caspofungin
  5. cImplementation within 48 h of mechanical ventilation initiation
  6. dImplementation within 72 h of mechanical ventilation initiation
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Journal of Intensive Care

ISSN: 2052-0492