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Table 1 Cohort characteristics stratified by %TTL tertiles

From: Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data

Patient factors

 

Overall (n = 500)

%TTL lowest tertile*

(n = 167)

%TTL middle tertile*

(n = 166)

%TTL highest tertile*

(n = 167)

Age (years)

Median [IQR]

59.5 [50.0, 67.3]

62.0 [51.5, 71.0]

59.0 [51.3, 66.0]

57.0 [44.0, 65.0]

Sex, male

n (%)

305 (61.0)

100 (59.9)

106 (63.9)

99 (59.3)

Race

n (%)

    

Black

 

39 (7.8)

11 (6.6)

10 (6.0)

18 (10.8)

White

 

449 (89.8)

152 (91.0)

151 (91.0)

146 (87.4)

Other or unknown

 

12 (2.4)

4 (2.4)

5 (3.0)

3 (1.8)

Body weight at ICU admission (kg)

Median [IQR]

93.7 [78.4, 113.0]

97.5 [83.6, 113.6]

92.7 [77.2, 114.5]

91.0 [76.0, 110.5]

Charlson comorbidity index

Median [iqr]

5 [3, 7]

5 [3, 7]

4 [2, 6]

5 [3, 7]

SOFA score at CRRT initiation

Median [iqr]

13 [11, 16]

14 [11, 16]

13 [11, 16]

13 [11, 15]

SOFA score at ICU admission

Median [iqr]

12 [9, 14]

12 [9, 14.50]

11 [9, 14]

12 [8.50, 14]

Baseline eGFR (mL/min/1.73m2)

Median [iqr]

41.6 [18.5, 74.8]

35.0 [18.2, 63.5]

48.4 [19.8, 80.5]

42.3 [17.7, 74.4]

Mechanical ventilation at CRRT initiation

N (%)

404 (80.8)

131 (78.4)

142 (85.5)

131 (78.4)

Cardiac support device at CRRT initiation

N (%)

52 (10.4)

18 (10.8)

21 (12.7)

13 (7.8)

Time from ICU admission to CRRT initiation (days)

Median [iqr]

1 [1, 4]

1 [1, 3]

1 [1, 4]

2 [0, 5]

%Fluid overload from ICU admission to CRRT initiation

Median [iqr]

0.92 [0, 4.67]

0.66 [0.00, 3.32]

0.92 [0.00, 5.18]

0.95 [0.00, 7.23]

Machine factors†

     

 Total alarms

Median [IQR]

2.67 [1.50, 4.72]

1.40 [0.60, 2.28]

2.81 [1.76, 4.03]

4.69 [2.93, 8.00]

 Catheter alarms

Median [IQR]

2.43 [1.29, 4.12]

1.25 [0.50, 2.00]

2.61 [1.67, 3.62]

4.29 [2.38, 6.73]

Access alarms

Median [IQR]

1.25 [0.50, 2.28]

0.50 [0.00, 1.14]

1.41 [0.76, 2.23]

2.08 [1.24, 3.50]

Return alarms

Median [IQR]

1.00 [0.43, 1.80]

0.50 [0.00, 1.00]

1.00 [0.50, 1.65]

1.55 [0.92, 3.00]

 Filter alarms

Median [IQR]

0.15 [0.00, 0.50]

0.00 [0.00, 0.29]

0.18 [0.00, 0.50]

0.38 [0.00, 0.86]

TMP alarms

Median [IQR]

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

FP alarms

Median [IQR]

0.12 [0.00, 0.41]

0.00 [0.00, 0.20]

0.17 [0.00, 0.40]

0.29 [0.00, 0.67]

Clotting alarms

Median [IQR]

0.00 [0.00, 0.05]

0.00 [0.00, 0.00]

0.00 [0.00, 0.08]

0.00 [0.00, 0.12]

 Fluid balance goal (mL/kg/day)

Median [IQR]

− 13.77 [− 20.04, − 8.25]

− 13.67 [− 21.72, − 5.22]

− 14.27 [− 18.44, − 9.78]

− 13.42 [− 19.82, − 8.20]

 Net fluid balance (mL/kg/day)

Median [IQR]

3.01 [− 5.96, 17.11]

9.95 [− 3.29, 28.39]

0.71 [− 7.95, 11.90]

2.50 [− 5.18, 10.89]

 FBgap (mL/kg/day)

Median [IQR]

17.37 [8.22, 30.39]

21.21 [10.23, 42.88]

14.49 [6.30, 25.49]

16.33 [9.30, 27.10]

 Total TTL during entire CRRT (hours)

Median [IQR]

6.38 [1.65, 15.80]

0.94 [0.22, 3.00]

9.81 [4.45, 17.52]

14.12 [6.73, 28.61]

 %TTL

Median [IQR]

8.14 [4.34, 12.45]

2.57 [1.20, 4.33]

8.14 [6.90, 9.48]

15.21 [12.48, 19.31]

  1. %TTL, percent treatment time loss; ICU, intensive care unit; SOFA, sequential organ failure assessment; eGFR, estimated glomerular filtration rate; TMP, transmembrane pressure; FP, filter pressure; FBgap, fluid balance gap; IQR, interquartile range
  2. *The tertile cutoffs for %TTL values are as follows: lowest: < 5.63%, middle: 5.63–10.76%, highest: ≥ 10.77%
  3. †The number of each alarm is the average per day
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Journal of Intensive Care

ISSN: 2052-0492