Table 1 Baseline characteristics and their association with day-28 mortality
Variable | Total | Survivors | Non-survivors | p value* |
|---|---|---|---|---|
At ICU admission | n = 995 | n = 599 | n = 396 | |
Age, median [IQR] | 68 [57.4–77.1] | 66.7 [55.4–75.9] | 69.8 [60.7–78.7] | < 0.001 |
Male sex, n (%) | 636 (63.9) | 372 (62.1) | 264 (66.7) | 0.226 |
Comorbidities, n (%) | ||||
Chronic liver disease, n (%) | 95 (9.5) | 41 (6.8) | 54 (13.6) | < 0.001 |
Chronic heart disease, n (%) | 194 (19.5) | 101 (16.9) | 93 (23.5) | 0.001 |
Chronic respiratory disease, n (%) | 150 (15.1) | 90 (15) | 60 (15.2) | 0.914 |
Chronic kidney disease, n (%) | 79 (7.9) | 42 (7) | 37 (9.3) | 0.131 |
Immunosuppression, n (%) | 199 (20) | 111 (18.5) | 88 (22.2) | 0.229 |
Alcoholism, n (%) | 218 (21.9) | 127 (21.2) | 91 (23) | 0.602 |
Smoking, n (%) | 271 (27.2) | 165 (27.5) | 106 (26.8) | 0.920 |
SAPS II, median [IQR] | 67 [55–79] | 63 [52–75] | 73 [61–85] | < 0.001 |
SOFA without neurological, median [IQR] | 9 [7–11] | 10 [8–12] | 13 [9–15] | < 0.001 |
Glasgow score, n (%) | ||||
3–8 | 649 (65.2) | 372 (62.1) | 277 (69.9) | 0.009 |
9–12 | 267 (26.8) | 170 (28.4) | 97 (24.5) | 0.142 |
13 | 79 (7.9) | 57 (9.5) | 22 (5.6) | 0.008 |
Medical admission, n (%) | 698 (70.2) | 401 (66.9) | 297 (75) | 0.007 |
Septic shock, n (%) | 963 (96.8) | 577 (96.3) | 386 (97.5) | 0.472 |
Early systemic insults within the first 48 h | ||||
Glycemia | ||||
Hypoglycemia (< 3 mmol/l), n (%) | 63 (6.5) | 23 (4) | 40 (10.3) | < 0.001 |
Hyperglycemia (> 11 mmol/l), n (%) | 333 (34.4) | 199 (34.3) | 134 (34.5) | 0.969 |
Blood pressure | ||||
Hypotension (DBP < 50 mmHg), n (%) | 803 (80.7) | 471 (78.6) | 332 (83.8) | 0.027 |
Temperature | ||||
Hypothermia (T°C < 36 °C), n (%) | 361 (36.3) | 199 (33.2) | 162 (40.9) | 0.009 |
Hyperthermia (T°C ≥ 38.3 °C), n (%) | 512 (51.5) | 314 (52.4) | 198 (50) | 0.457 |
Anemia | ||||
Hematocrit < 21%, n (%) | 175 (17.7) | 86 (14.4) | 89 (22.6) | 0.001 |
Natremia | ||||
Hyponatremia (< 135 mmol/l), n (%) | 350 (35.2) | 209 (34.9) | 141 (35.6) | 0.808 |
Hypernatremia (> 145 mmol/l), n (%) | 164 (16.5) | 95 (15.9) | 69 (17.4) | 0.633 |
Oxygenation | ||||
Hypoxemia (PaO2 < 60 mmHg), n (%) | 126 (12.7) | 67 (11.2) | 59 (14.9) | 0.070 |
Hyperoxia (PaO2 > 200 mmHg), n (%) | 201 (20.2) | 121 (20.2) | 80 (20.2) | 0.655 |
Capnia | ||||
Hypocapnia (PaCO2 < 35 mmHg), n (%) | 497 (50) | 309 (51.7) | 188 (47.5) | 0.060 |
Hypercapnia (PaCO2 > 45 mmHg), n (%) | 325 (32.7) | 197 (32.9) | 128 (32.3) | 0.764 |