Fig. 2
From: Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock
Mendelian randomization analyses for the change in 28-day mortality in septic shock. A Inverse variance weighted model. The odds ratio of 28-day mortality to a decrease in apolipoprotein A-II 1 mg/dL was 1.03 (95% CI; 1.01–1.05, P = 0.009). B A two-sample Mendelian randomization to the VASST cohort using effect sizes for apolipoprotein A-II from the Japan cohort. The odds ratio of 28-day mortality for a decrease in apolipoprotein A-II concentration of 1 mg/dL was 1.03 (95% CI; 1.00–1.04, P = 0.21). In a meta-analysis, the integrated odds ratio was 1.02 (95% CI; 1.01–1.03, P = 0.0022)