Table 1 Baseline characteristics in the derivation cohort by hospital mortality (Japan cohort, n = 687)
From: Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock
|  | Survive (n = 473) | Dead (n = 214) | P-value |
|---|---|---|---|
Age, yr | 69 (57–77) | 70 (62–76) | 0.18 |
Male sex, n (%) | 307 (64.9) | 139 (65.0) | 1.00 |
BMI, kg/m2 | 23 (20–26) | 22 (19–25) | 0.030 |
APACHE II score1 | 28 (22–34) | 36 (29–40) | < 0.001 |
SOFA score2 | 12 (9–15) | 15 (12–17) | < 0.001 |
Comorbidity, n (%) | |||
 Diabetes mellitus | 122 (25.8) | 47 (22.0) | 0.29 |
 Dyslipidemia | 62 (13.1) | 22 (10.3) | 0.32 |
 Congestive heart failure | 38 (8.0) | 25 (11.7) | 0.15 |
 End stage renal failure | 30 (6.3) | 25 (11.7) | 0.022 |
 Chronic pulmonary disease | 25 (5.3) | 18 (8.4) | 0.13 |
Lipid laboratory data on Day1 | |||
 HDL cholesterol, mg/dL | 29 (18–42) | 27 (15–42) | 0.18 |
 LDL cholesterol, mg/dL | 41 (21–66) | 37 (17–62) | 0.17 |
 Total cholesterol, mg/dL | 105 (79–140) | 101 (68–133) | 0.045 |
 Apolipoprotein A-I, mg/dL | 70 (47–94) | 60 (38–84) | 0.007 |
 Apolipoprotein A-II, mg/dL | 12.0 (8.5–16.8) | 9.9 (6.2–13.8) | < 0.001 |
 Apolipoprotein B, mg/dL | 54 (38–76) | 50 (35–73) | 0.18 |
 Apolipoprotein C-III, mg/dL | 4.7 (3.1–6.6) | 4.2 (2.6–5.6) | 0.046 |
 Apolipoprotein E, mg/dL | 3.7 (2.9–5.1) | 3.8 (2.8–5.0) | 0.84 |