Table 1 Characteristics of the discovery cohort and validation cohort
From: Low expression of CD39 on monocytes predicts poor survival in sepsis patients
Characteristics | Discovery cohort | Validation cohort | |||||
|---|---|---|---|---|---|---|---|
Healthy donor N=10 | Mild infection N=15 | Surgery N=15 | Sepsis N=15 | Mild infection N=49 | Surgery N=36 | Sepsis N=66 | |
Age-- yr | 51±7 | 51±20 | 57±12 | 69±10 | 66±14 | 62±12 | 67±12 |
Gender-- No. (%) | |||||||
   Male | 6(60) | 10(67) | 9(60) | 9(60) | 28(57) | 17(47) | 48(73) |
   Female | 4(40) | 5(33) | 6(40) | 6(40) | 21(43) | 19(53) | 18(27) |
Coexisting conditions -- No. (%) | |||||||
   Diabetes |  | 0 | 1(7) | 6(40) | 7(14) | 4(11) | 13(20) |
   Hypertension |  | 1(7) | 8(53) | 4(27) | 22(45) | 18(50) | 36(55) |
   Heart disease |  | 0 | 15(100) | 4(27) | 8(16) | 36(100) | 16(24) |
   Chronic pulmonary disease |  | 2(13) | 0 | 1(7) | 8(16) | 1(3) | 4(6) |
Most common Primary sources of infection -- No. (%) | |||||||
   Pneumonia |  | 4(27) |  | 4(27) | 45(92) |  | 31(47) |
   Urinary tract infection |  | 2(13) |  | 3(20) | 3(6) |  | 4(6) |
   Intra-abdominal infection |  | 9(60) |  | 8(53) | 1(2) |  | 20(30) |
   Bloodstream infection |  | 0 |  | 0 | 0 |  | 11(17) |
Laboratory Testing | |||||||
   WBC count (IQR) -- 1000/mm3 |  | 12.51(8.38-18.10) | 9.82(9.15-11.41) | 14.48(4.73-19.50) | 7.34(5.51-10.27) | 10.51(8.45-12.33) | 12.93(6.80-17.48) |
   CRP (IQR) -- mg/L |  | 167.17(102.53-198.74) | 39.04(30.41-64.25) | 200.71(149.46-237.45) | 39.85(24.23-107.00) | 41.91(23.12-61.67) | 146.48(67.49-228.72) |
   PCT (IQR) -- ng/mL |  | 0.71(0.18-1.38) | 0.76(0.42-3.30) | 60.9(15.40-100.00) | 0.12(0.06-0.35) | 0.34(0.15-1.00) | 8.07(1.64-68.68) |
   Creatinine (IQR) -- μmol/L |  | 67(60-84) | 94(64-119) | 160(130-176) | 60(51-71) | 72(60-86) | 107(80-181) |
   ALT (IQR) --U/L |  | 20(16-31) | 14(12-21) | 33(15-53) | 19(10-37) | 16(11-22) | 22(14-59) |
   AST (IQR) -- U/L |  | 23(18-26) | 26(23-58) | 56(39-84) | 22(15-38) | 40(25-59) | 46(28-80) |
   TBIL (IQR) -- μmol/L |  | 11.8(8.9-17.5) | 16.3(15.1-21.3) | 28.5(21.8-45.8) | 6.6(5.3-12.9) | 14.2(10.9-19.4) | 15.7(10.5-36.0) |
APACHE II score |  |  | 10.73±2.40 | 22.60±6.22 |  | 12.94±3.72 | 22.83±7.09 |
SOFA score |  | <2 | 4.47±2.00 | 10.53±2.67 | <2 | 6.22±2.32 | 10.22±4.55 |