Table 5 Mediation analysis of EPO in the association between lactate and 28-day mortality
| Â | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | |
Total effect | 0.0824 (0.0578–0.1297) | <0.0001 | 0.0837 (0.0591–0.1302) | <0.0001 | 0.0648 (0.0346–0.1164) | <0.0001 |
Mediation effect | 0.0156 (0.0073–0.3402) | <0.0001 | 0.0169 (0.0080–0.0256) | <0.0001 | 0.0082 (0.0023–0.0153) | <0.0040 |
Direct effect | 0.0668 (0.0709–0.3152) | <0.0001 | 0.0668 (0.0425–0.1148) | <0.0001 | 0.0566 (0.0265–0.1075) | <0.0001 |
Proportion mediated | 0.1894 (0.0827–0.3402) | <0.0001 | 0.2015 (0.0820–0.3249) | <0.0001 | 0.1259 (0.0265–0.1075) | <0.0040 |